Heads up! We may use affiliate links in this post. You'll never pay more, but we might earn a small commission if you buy - thanks for supporting us! See our full disclosure here.
When it comes to building a skincare routine that ACTUALLY works, layering ingredients can feel like equal parts art and science. You’ve probably heard the buzz around azelaic acid and niacinamide—both praised for their ability to calm, brighten, and clarify skin.
But using them together? That’s where the questions start.
Can they cancel each other out? Irritate sensitive skin? Make your current serum lineup less effective?
Spoiler: not only can these two skincare ingredients coexist, they actually complement each other beautifully—especially for acne-prone skin, uneven skin tone, or anyone trying to support a strong skin barrier without triggering irritation.
Below, everything you need to know about pairing azelaic acid with niacinamide, plus skincare tips on how to layer them the right way—alongside other actives like salicylic acid, glycolic acid, or hyaluronic acid—depending on your skin type.
Understanding Azelaic Acid and Niacinamide
Azelaic acid has quietly become one of skincare’s most reliable multitaskers. Naturally derived from grains and also produced by the skin’s microbiome, this ingredient is known for its ability to calm inflammation, target breakouts, and fade post-acne marks.
As Typology Paris explains, “it is used to mattify and even out the complexion, to fight effectively against imperfections and to reduce pigmentation spots.” In short: it’s gentle, but it gets the job done—especially for those dealing with acne, uneven skin, or sensitive skin.
Niacinamide, a form of vitamin B3, is another ingredient with an impressive resumé. It strengthens the skin barrier, smooths texture, and helps regulate oil production, making it especially valuable for those with oily skin or prone skin.
According to skincare brand founder Marta Masi, who spoke to Vogue, niacinamide can help to “alleviate this skin concern and give skin a healthier color. It also prevents collagen from breaking down in the glycation process.” In other words, it not only corrects current concerns, but also works behind the scenes to slow signs of ageing, like fine lines and dullness.
SHOP OUR TOP 3 FAVOURITES
1. Naturium Azelaic Topical Acid 10%
A cult favourite for a reason, this cream-serum hybrid pairs azelaic acid with niacinamide, vitamin C derivatives, and salicylic acid in a non-irritating formula that targets uneven skin tone, breakouts, and dullness.
2. Paula’s Choice 10% Azelaic Acid Booster
This is technically a booster (meaning you can mix it into other products), but it already contains niacinamide along with azelaic acid and salicylic acid. It’s designed to reduce the look of blemishes and brighten uneven skin, all while helping to refine texture and calm redness.
3. Agency by Curology – Future Formula
This prescription-strength formula is designed with customisation in mind, and it often includes azelaic acid and niacinamide, alongside other targeted actives like tretinoin, ascorbic acid, or tranexamic acid—based on your specific skin goals. It’s ideal for treating acne, uneven skin tone, fine lines, and even melasma.
Benefits of Combining Azelaic Acid and Niacinamide
When used together, azelaic acid and niacinamide can address multiple skin concerns:
- Acne and Blemishes: Azelaic acid’s antibacterial properties help in reducing acne, while niacinamide soothes inflammation and redness.
- Hyperpigmentation: Both ingredients work synergistically to fade dark spots and even out skin tone.
- Skin Texture and Tone: The combination promotes smoother skin by reducing roughness and improving overall complexion.
- Sensitive Skin: Niacinamide enhances the skin’s barrier function, making it more resilient and less prone to irritation from active ingredients like azelaic acid.
How to Incorporate Them into Your Skincare Routine
- Cleansing: Start with a gentle cleanser suitable for your skin type to remove impurities without stripping the skin’s natural oils.
- Niacinamide Serum: Apply a niacinamide serum to clean, dry skin. This allows it to penetrate effectively and start strengthening the skin barrier.
- Azelaic Acid: After the niacinamide serum has absorbed, apply azelaic acid. Depending on the formulation (gel, cream, or foam), follow the product instructions for optimal results.
- Moisturiser: Finish with a moisturiser to lock in hydration. If your skin is particularly dry or sensitive, look for products containing hyaluronic acid or ceramides.
- Sunscreen (Morning Routine): In the morning, always apply a broad-spectrum sunscreen with at least SPF 30 after your moisturiser to protect your skin from UV damage.
Additional Skincare Tips
- Patch Test: Before introducing new products, perform a patch test to ensure your skin doesn’t react adversely.
- Introduce Gradually: If you’re new to these ingredients, start by using them on alternate days to monitor how your skin responds.
- Avoid Over-Exfoliation: Be cautious when combining azelaic acid with other exfoliating agents like salicylic acid, glycolic acid, or mandelic acid, as this can lead to irritation.
- Consistency is Key: Regular use of these ingredients will yield the best results. However, if you experience persistent irritation, consult a dermatologist.
Conclusion
So, can you combine azelaic acid and niacinamide – ABSOLUTELY! In fact, it’s an effective strategy for addressing various skin concerns, including acne, uneven skin tone, and sensitivity.
By incorporating them thoughtfully into your skincare routine, you can harness their synergistic benefits for healthier, more radiant skin.
